25 Hotels TRULY CLOSEST to South Main Street Houston, TX | HotelGuides.com
Our Customers Have Booked Almost 5,000,000 Hotel Reservations
     
Check Rates for Hotels near South Main Street Houston
 Pet Friendly Only
10+ Rooms Kids Free

Hotel Guides > Texas > Houston > Hotels near South Main Street

Hotels and Motels near South Main Street – Houston, TX


Use this guide to find hotels and motels near South Main Street in Houston, Texas.

Map of Hotels and Motels near South Main Street Houston
 

    Hotels closest to South Main Street Houston

    Rates shown below are averages. Click See Rates to see rates for your dates.
  • Courtyard by Marriott Hotel Medical Center Houston
    7702 Main Street, Houston, TX 77030

    From $93
    Enter Dates
    Courtyard by Marriott Hotel Medical Center Houston

    Check In1500
    Check Out1200

    Rated High
  • Upper-midscale, smoke-free hotel near NRG Park and Stadium
  • Outdoor swimming pool open all year - exercise room
  • Free WiFi
  • Parking costs $6 per night - one space per room
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 427 reviews  Read Recent Reviews

  • Residence Inn by Marriott Medical Center Houston
    7807 Kirby Drive, Houston, TX 77030

    From $373
    Enter Dates
    Residence Inn by Marriott Medical Center Houston

    Check In1600
    Check Out1200

    Rated Very High
  • Upscale, smoke-free, all-suite, extended-stay hotel
  • Near NRG Stadium
  • Heated indoor swimming pool - exercise room
  • Free hot breakfast buffet
  • Free WiFi
  • Parking costs $7 per night
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.5 of 5 stars
    Based on 18 reviews  Read Recent Reviews

  • Americas Best Value Inn NRG Park Houston
    7905 South Main St and Old Spanish Trail, Houston, TX 77025

    From $75
    Enter Dates
    Americas Best Value Inn NRG Park Houston

    Check In13 00
    Check Out12 00

    Rated Low – Not Recommended
  • Cheap, smoke-free motel
  • 3 blocks north of NRG Park and Stadium
  • No swimming pool
  • Free continental breakfast
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.0 of 5 stars
    Based on 46 reviews  Read Recent Reviews

  • Extended Stay America Hotel La Concha Houston
    1303 La Concha Lane, Houston, TX 77054

    From $104
    Enter Dates
    Extended Stay America Hotel La Concha Houston

    Check In15 00
    Check Out11 00

    Rated Average
  • Budget, smoke-free, all-suite, extended-stay hotel
  • Near NRG Park and Houston Medical Center
  • Free shuttle to Texas Medical Center
  • Outdoor swimming pool open in summer - exercise room
  • Free continental breakfast
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 132 reviews  Read Recent Reviews

  • Hotel Ylem Houston
    8080 Main Street, Houston, TX 77025

    From $139
    Enter Dates
    Hotel Ylem Houston

    Check In15 00
    Check Out12 00

    Rated Average
  • Upscale, smoke-free hotel near NRG Park and Stadium
  • An Ascend Collection Hotel Member
  • No swimming pool
  • Exercise room
  • Free hot breakfast buffet
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.5 of 5 stars
    Based on 189 reviews  Read Recent Reviews

  • Hampton Inn & Suites Medical Center Houston
    1715 Old Spanish Trail, Houston, TX 77054

    From $169
    Enter Dates
    Hampton Inn & Suites Medical Center Houston

    Check In16 00
    Check Out11 00

    Rated Average
  • Midscale, smoke-free hotel 1 mile north of NRG Park
  • 1 mile west of VA Hospital - 2 blocks from metrorail station
  • Free shuttle to attractions within 3-mile radius
  • Outdoor swimming pool - exercise room
  • Free continental breakfast
  • Free WiFi
  • Parking costs $6 per night
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 885 reviews  Read Recent Reviews

  • Holiday Inn South Loop Houston
    8111 Kirby Drive at LaConcha, Houston, TX 77054

    From $142
    Enter Dates
    Holiday Inn South Loop Houston

    Check In15 00
    Check Out12 00

    Rated Average
  • Upper-midscale, smoke-free, full-service hotel
  • 2 blocks from NRG Park and Stadium
  • Free shuttle to local attractions
  • Outdoor swimming pool - exercise room
  • Free WiFi
  • Free parking - truck parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.5 of 5 stars
    Based on 379 reviews  Read Recent Reviews

  • Rodeway Inn & Suites Medical Center Houston
    6712 Morningside Drive, Houston, TX 77030

    From $54
    Enter Dates
    Rodeway Inn & Suites Medical Center Houston

    Check In15 00
    Check Out11 00

    Rated Low – Not Recommended
  • Cheap, smoke-free motel near Houston Medical Center
  • Near MD Anderson Center and Rice University
  • Free shuttle to Texas Medical Center
  • No swimming pool
  • Free continental breakfast
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.0 of 5 stars
    Based on 9 reviews  Read Recent Reviews

  • Extended Stay America Hotel Medical Center Braeswood Houston
    1301 South Braeswood Blvd, Houston, TX 77030

    From $90
    Enter Dates
    Extended Stay America Hotel Medical Center Braeswood Houston

    Check In15 00
    Check Out11 00

    Rated Low – Not Recommended
  • Budget, smoke-free, all-suite, extended-stay hotel
  • Near Houston Medical Center
  • Closest hotel to VA Hospital
  • Outdoor swimming pool - exercise room
  • Free continental breakfast
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    Warning: This hotel overbooked and did not honor a confirmed reservation. - May 2019
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.0 of 5 stars
    Based on 267 reviews  Read Recent Reviews

  • Wyndham Hotel & Suites Medical Center Houston
    6800 South Main Street, Houston, TX 77030

    From $168
    Enter Dates
    Wyndham Hotel & Suites Medical Center Houston

    Check In1500
    Check Out1200

    Rated High
  • Upper-midscale, smoke-free hotel
  • Near Houston Medical Center and Rice University
  • Easy access to MD Anderson Cancer Center
  • Also near METRORail
  • Free shuttle to local attractions
  • Outdoor swimming pool open in summer
  • Exercise room
  • Free WiFi
  • Parking costs $15 per night
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 1246 reviews  Read Recent Reviews

  • InterContinental Hotel Medical Center Houston
    6750 Main Street, Houston, TX 77030

    From $126
    Enter Dates
    InterContinental Hotel Medical Center Houston

    Check In15 00
    Check Out12 00

    Rated Very High
  • Upscale, smoke-free hotel by Texas Medical Center
  • Heated outdoor swimming pool open in summer
  • 24-hour exercise room
  • Free WiFi
  • Parking costs $22 per night
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.5 of 5 stars
    Based on 76 reviews  Read Recent Reviews

  • Surestay Plus Hotel by Best Western Houston Medical Center
    6700 Main Street, Houston, TX 77030

    From $128
    Enter Dates
    Surestay Plus Hotel by Best Western Houston Medical Center

    Check In1500
    Check Out1200

    Rated Average
  • Midscale, smoke-free hotel near Houston Methodist Hospital
  • Also near Rice University and Texas Medical Center
  • 1 mile from zoo
  • Free shuttle to local attractions
  • Heated indoor swimming pool - exercise room
  • Free hot breakfast buffet
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.5 of 5 stars
    Based on 759 reviews  Read Recent Reviews

  • Extended Stay America Hotel NRG Park Houston
    7979 Fannin Street, Houston, TX 77054

    From $50
    Enter Dates
    Extended Stay America Hotel NRG Park Houston

    Check In15 00
    Check Out11 00

    Rated Very Low – Not Recommended
  • Budget, smoke-free, all-suite, extended-stay hotel
  • Across street from NRG Center
  • No swimming pool
  • Free continental breakfast
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  2.5 of 5 stars
    Based on 206 reviews  Read Recent Reviews

  • Hilton Plaza Hotel Houston
    6633 Travis Street, Houston, TX 77030

    From $161
    Enter Dates
    Hilton Plaza Hotel Houston

    Check In15 00
    Check Out12 00

    Rated Average
  • Upscale, smoke-free, full-service hotel
  • Near Houston Medical Center
  • Also near Rice University and Zoo
  • Free shuttle to attractions within 2-mile radius
  • Outdoor swimming pool - exercise room
  • Free WiFi
  • Parking costs $12 per night
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.5 of 5 stars
    Based on 1033 reviews  Read Recent Reviews

  • Staybridge Suites Medical Center Houston
    9000 South Main Street, Houston, TX 77025

    From $88
    Enter Dates
    Staybridge Suites Medical Center Houston

    Check In15 00
    Check Out11 00

    Rated High
  • Upscale, smoke-free, all-suite, extended-stay hotel
  • Near NRG Stadium
  • Outdoor swimming pool - 24-hour exercise room
  • Free hot breakfast buffet
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 26 reviews  Read Recent Reviews

  • Marriott Hotel at Texas Medical Center Houston
    6580 Fannin Street, Houston, TX 77030

    From $259
    Enter Dates
    Marriott Hotel at Texas Medical Center Houston

    Check In1600
    Check Out1200

    Rated Very High
  • Upscale, smoke-free, full-service hotel
  • Near Houston Medical Center and Rice University
  • Skyway to medical schools and Methodist Hospital
  • Skyway to Scurlock and Smith Towers
  • Free shuttle to attractions within 2-mile radius
  • Heated indoor swimming pool - exercise room
  • Free WiFi
  • Valet parking only - $28 per night
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.5 of 5 stars
    Based on 1063 reviews  Read Recent Reviews

  • Holiday Inn Express Hotel & Suites Medical Center Houston
    9300 South Main Street, Houston, TX 77025

    From $121
    Enter Dates
    Holiday Inn Express Hotel & Suites Medical Center Houston

    Check In15 00
    Check Out12 00

    Rated High
  • Midscale, smoke-free hotel near NRG Park and Stadium
  • Free shuttle to Houston Medical Center
  • Outdoor swimming pool - 24-hour exercise room
  • Free hot breakfast buffet
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.5 of 5 stars
    Based on 106 reviews  Read Recent Reviews

  • Crowne Plaza Hotel Medical Center Houston
    8686 Kirby Drive at I-610 South, Houston, TX 77054

    From $112
    Enter Dates
    Crowne Plaza Hotel Medical Center Houston

    Check In15 00
    Check Out11 00

    Rated Average
  • Upscale, smoke-free, full-service hotel
  • Across the street from NRG Park
  • Outdoor swimming pool - 24-hour exercise room
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.0 of 5 stars
    Based on 493 reviews  Read Recent Reviews

  • Candlewood Suites Medical Center Houston
    10025 Main Street, Houston, TX 77025

    From $76
    Enter Dates
    Candlewood Suites Medical Center Houston

    Check In15 00
    Check Out12 00

    Rated Average
  • Midscale, smoke-free, all-suite, extended-stay hotel
  • Near NRG Park
  • Free shuttle within a 5-mile radius
  • Indoor swimming pool - 24-hour exercise room
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 97 reviews  Read Recent Reviews

  • Econo Lodge Zoo Houston
    3138 Old Spanish Trail, Houston, TX 77054

    From $81
    Enter Dates
    Econo Lodge Zoo Houston

    Check In15 00
    Check Out11 00

    Rated Very Low – Not Recommended
  • Cheap, smoke-free motel
  • No swimming pool
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  1.5 of 5 stars
    Based on 16 reviews  Read Recent Reviews

  • MainStay Suites Medical Center Houston
    3134 Old Spanish Trail, Houston, TX 77054

    From $139
    Enter Dates
    MainStay Suites Medical Center Houston

    Check In15 00
    Check Out11 00

    Rated Average
  • Midscale, smoke-free, all-suite, extended-stay hotel
  • Located near NRG Park and NRG Stadium
  • Free shuttle to Houston Medical Center
  • Free shuttle to other attractions within 3-mile radius
  • Heated outdoor swimming pool - exercise room
  • Free continental breakfast
  • Free WiFi
  • Free parking - truck parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 364 reviews  Read Recent Reviews

  • Courtyard by Marriott Hotel West University Houston
    2929 Westpark Drive, Houston, TX 77005

    From $71
    Enter Dates
    Courtyard by Marriott Hotel West University Houston

    Check In1500
    Check Out1200

    Rated High
  • Upper-midscale, smoke-free hotel
  • 2 miles northwest of Rice University
  • Outdoor swimming pool - exercise room
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 197 reviews  Read Recent Reviews

  • Residence Inn by Marriott West University Houston
    2939 Westpark Drive, Houston, TX 77005

    From $93
    Enter Dates
    Residence Inn by Marriott West University Houston

    Check In1500
    Check Out1200

    Rated High
  • Upscale, smoke-free, all-suite, extended-stay hotel
  • 1 mile east of Greenway Plaza
  • Free shuttle to attractions within 3-mile radius
  • Outdoor swimming pool - 24-hour exercise room
  • Free hot breakfast buffet
  • Free WiFi
  • Free parking - truck parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 179 reviews  Read Recent Reviews

  • Hotel ZaZa Houston
    5701 Main Street, Houston, TX 77005

    From $248
    Enter Dates
    Hotel ZaZa Houston

    Check In16 00
    Check Out12 00

    Rated Very High
  • Upscale, smoke-free, full-service hotel
  • Near Houston Medical Center
  • Also near Rice University
  • Free shuttle to attractions within 5-mile radius
  • Outdoor swimming pool - exercise room
  • Free WiFi
  • Valet parking only - $30 per night
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.5 of 5 stars
    Based on 2014 reviews  Read Recent Reviews

  • Extended Stay America Hotel Southwest Houston
    2330 SW Freeway, US 59, Houston, TX 77098

    From $54
    Enter Dates
    Extended Stay America Hotel Southwest Houston

    Check In15 00
    Check Out11 00

    Rated Average
  • Budget, smoke-free, all-suite, extended-stay hotel
  • 1 mile northwest of Rice University
  • No swimming pool
  • Free continental breakfast
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.5 of 5 stars
    Based on 169 reviews  Read Recent Reviews

  • Crowne Plaza Hotel River Oaks Houston
    2712 SW Freeway, US 59, Houston, TX 77098

    From $77
    Enter Dates
    Crowne Plaza Hotel River Oaks Houston

    Check In15 00
    Check Out11 00

    Rated Average
  • Upscale, smoke-free, full-service hotel
  • 1 mile northwest of Rice University
  • Free shuttle to attractions within 3-mile radius
  • Outdoor swimming pool - 24-hour exercise room
  • Free WiFi
  • Parking costs $10 per night
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 1794 reviews  Read Recent Reviews

  • DoubleTree by Hilton Hotel Greenway Plaza Houston
    6 Greenway Plaza East, Houston, TX 77046

    From $92
    Enter Dates
    DoubleTree by Hilton Hotel Greenway Plaza Houston

    Check In15 00
    Check Out12 00

    Rated High
  • Upscale, smoke-free, full-service hotel
  • 5 miles southwest of downtown Houston
  • Free shuttle to attractions within 3-mile radius
  • Heated outdoor swimming pool - 24-hour exercise room
  • Internet access costs $13 per night
  • Parking costs $18 per night
  • Not pet friendly - no pets allowed.
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 1285 reviews  Read Recent Reviews

  • La Quinta Inn Greenway Plaza Houston
    4015 SW Freeway, US 59, Houston, TX 77027

    From $79
    Enter Dates
    La Quinta Inn Greenway Plaza Houston

    Check In15 00
    Check Out12 00

    Rated Average
  • Midscale, smoke-free hotel
  • 5 miles northwest of Houston Medical Center
  • Free shuttle to Houston Medical Center
  • Outdoor swimming pool open in summer
  • Free continental breakfast
  • Free WiFi
  • Free parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.0 of 5 stars
    Based on 579 reviews  Read Recent Reviews

  • La Colombe d'Or Hotel Houston
    3410 Montrose Blvd, Houston, TX 77006

    From $225
    Enter Dates
    La Colombe d'Or Hotel Houston

    Check In16 00
    Check Out11 00

    Rated High
  • Luxury, smoke-free, all-suite, mansion hotel
  • 3 miles north of Houston Medical Center
  • No swimming pool
  • Free WiFi
  • Free parking
  • Not pet friendly - no pets allowed.
    TripAdvisor Traveler Rating:  4.0 of 5 stars
    Based on 40 reviews  Read Recent Reviews

  • Candlewood Suites Galleria Houston
    4900 Loop Central Drive, Houston, TX 77081

    From $72
    Enter Dates
    Candlewood Suites Galleria Houston

    Check In15 00
    Check Out12 00

    Rated Average
  • Midscale, smoke-free, all-suite, extended-stay hotel
  • 1.5 miles south of Galleria Mall
  • No swimming pool
  • 24-hour exercise room
  • Free WiFi
  • Free parking - truck parking
  • Pet friendly hotel More >
    Most Recent HotelGuides Reviews Read >
    TripAdvisor Traveler Rating:  3.5 of 5 stars
    Based on 113 reviews  Read Recent Reviews

  • Why Book Here?
    • No fees
    • Lowest price guarantee
    • Pay at hotel in most cases
    • If you don't like your hotel,
      we'll refund your money.
    • Cash rewards + hotel points too
  • See more reasons
Hotel Guides is Made in USA
Houston Info

Houston Hotels and Reviews

Houston Group Hotel Rates

Map of Hotels near South Main Street Houston



Nearby Attractions


Hotels near Shriners Hospital Houston   0.5 mile NE
Hotels near Fannin Street Houston   0.5 mile east
Hotels near UT Health Science Center Houston   0.6 mile NE
Hotels near Woman's Hospital of Texas   0.7 mile SE
Hotels near TWU Institute of Health Sciences   0.7 mile NE
Hotels near Houston NRG Center   0.8 mile south
Hotels near Houston Livestock Show and Rodeo   0.9 mile south
Hotels near Texas Children's Hospital   0.9 mile NE
Hotels near Baylor St Luke's Medical Center   0.9 mile NE
Hotels near Texas Medical Center   0.9 mile NE
Hotels near Texas Heart Institute   0.9 mile NE
Hotels near Houston Astrodome   1.0 mile south
Hotels near NRG Stadium   1.0 mile south
Hotels near Texas Bowl   1.0 mile south
Hotels near Houston Methodist Hospital   1.0 mile NE

Earn Cash Rewards plus Hotel Reward Points

How Do We Order Hotels?

We order the hotels on this page by how close they are to this attraction.

Most of our competitors order these same hotels in other ways that make them more money.
How Do We Define Motel?

To us, motels are smaller lodgings that have rooms you can enter directly from the parking area.

At hotels, on the other hand, you can enter your room only through a hall inside the building.
Hotel Tips

Important Hotel Tips


Hotels, Motels, Lodging, and Accommodations near South Main Street - Houston, Texas TX, USA

© 2020 HotelGuides.com, Inc. All rights reserved.

About Us | Terms of Use | Privacy Policy | Security | Contact Us



Home - HotelGuides.com US Hotels Canada Hotels Hotels in other countries View, change, or cancel my reservations Customer Service Our Better Business Bureau rating is A+ Hotel Guides is Made in USA
Hotel Guides

Just a moment while we find

the best deals at the best hotels.