The closest hotels on I-64 west of Lexington are in Covington, Virginia.
Lexington Hotels I-64 at US 11, Exit 55 near Virginia Horse Center
Lexington Hotels I-64 at I-81 at US 11, Exit 195
I-64 and I-81 begin to run concurrently in Lexington exit numbers then follow I-81
The closest I-64 hotels northeast of Lexington are in Raphine, Virginia.