Hotels between San Francisco and Yosemite National Park are located along I-580, I-205 and CA 120 in California. Yosemite is 167 miles east of San Francisco.
From West to East
The route from San Francisco to Yosemite National Park begins by leaving downtown San Francisco across the Bay Bridge via I-80 to I-580 in Oakland ... to I-205 near Tracy ... leads to CA 120 near Manteca which continues to the Big Oak Flat Entrance of Yosemite.
Yosemite National Park is located in eastern California near the border with Nevada. It is approximately 1189 square miles and includes part of the Sierra Nevada mountain range. The park has five entrances.