I-4 Hotels West to East FL
I-5 Hotels North to South WA, OR, CA
I-5 Hotels in Northern California North to South Yreka to Sacramento
I-10 Hotels West to East AZ, NM, TX, LA, MS, AL, FL
I-12 Hotels in Baton Rouge West to East LA
I-15 Hotels North to South ID, UT, NV, CA
I-16 Hotels West to East GA
I-17 Hotels North to South AZ
I-20 Hotels West to East TX, LA, MS, AL, GA, SC
I-22 Hotels West to East MS, AL
I-24 Hotels West to East IL, KY, TN
I-25 Hotels North to South WY, CO, NM
I-26 Hotels West to East TN, NC, SC
I-27 Hotels North to South TX
I-29 Hotels North to South ND, SD, IA, MO
I-30 Hotels West to East TX, AR
I-35 Hotels North to South MN, IA, MO, KS, OK, TX
I-39 Hotels North to South WI, IL
I-40 Hotels West to East AZ, NM, TX, OK, AR, TN, NC
I-44 Hotels West to East TX, OK, MO
I-45 Hotels North to South TX
I-49 Hotels North to South AR, LA
I-55 Hotels North to South IL, MO, AR, TN, MS, LA
I-57 Hotels North to South IL, MO
I-59 Hotels North to South GA, AL, MS, LA
I-64 Hotels West to East MO, IL, IN, KY, WV, VA
I-65 Hotels North to South IN, KY, TN, AL
I-66 Hotels in VA West to East
I-69 Hotels North to South MI, IN
I-70 Hotels West to East UT, CO, KS, MO, IL, IN, OH, WV, PA, MD
I-71 Hotels North to South OH, KY
I-74 Hotels in IL, IN, OH West to East
I-74 Hotels in NC West to East
I-75 Hotels North to South MI, OH, KY, TN, GA, FL
I-76 Hotels in CO West to East
I-76 Hotels in OH, PA West to East
I-77 Hotels North to South WV, VA, NC, SC
I-78 Hotels West to East PA, NJ
I-79 Hotels North to South PA, WV
I-80 Hotels West to East NV, UT, WY, NE, IA, IL, IN, OH, PA, NJ
I-81 Hotels North to South NY, PA, MD, WV, VA, TN
I-84 Hotels in PA, NY, CT, MA West to East
I-84 Hotels in OR, ID, UT West to East
I-85 Hotels North to South VA, NC, SC, GA, AL
I-87 Hotels North to South NY
I-90 Hotels West to East WA, ID, MT, WY, SD, MN, WI, IL, IN, OH, PA, NY, MA
I-94 Hotels West to East ND, MN, WI, IL, IN, MI
I-95 Hotels North to South CT, NY, NJ, PA, DE, MD, VA, NC, SC, GA, FL
I-210 Hotels West to East California
I-210 Hotels West to East Lake Charles, LA
I-240 Hotels West to East Oklahoma City, OK
I-283 Hotels North to South Harrisburg, PA
I-495 Hotels in Camp Springs MD Capital Beltway around Washington, DC
I-495 Hotels in Largo MD Capital Beltway around Washington, DC
I-495 Hotels in Massachusetts North to South
Florida Turnpike Hotels North to South
Long Island Expressway, Exit 63 Hotels I-495 in Holtsville, NY
New Jersey Turnpike Hotels North to South
Ohio Turnpike Hotels West to East
Route 66 Hotels East to West